2023 Being head boy or indeed having any other position of responsibility in the English schooling system was unlikely to be in the cards for O’Connor, whose career in stunts and gags and general detention-earning charm had been somewhat stellar. Jonah Valdez, Los Angeles Times, 24 Aug. 2023 And even after online backlash that the gag was too soon, Mandel is defending the moment and claiming Vergara was in on the joke. Robert Lloyd, Los Angeles Times, 8 Aug. 2023 Where the comic is highly conceptual, with discrete gags typically delivered in the space of four panels, the series requires something meatier, with more action, identifiable characters and narrative and emotional arcs, which come in longer and shorter varieties. Samantha Jones, Better Homes & Gardens, 24 Aug. 2023 Though some rules ask attendees to bring gag gifts to a white elephant exchange, others may iterate small purchases. 2023 Break the ice with a great gag gift for the couple in your life. 2023 The characters are nothing but a handful of overt desires and idiosyncratic mannerisms, and their actions seem to exist solely to slot into the plot and to generate gags. 2023 The New Yorker The artist scribbled gags in pencil on her ink-wash cartoons, touching on themes of romance, motherhood, and body image. Noun One running gag about a salmon-shagging sushi chef is particularly limp, not to mention racially dubious. Arricca Elin Sansone, House Beautiful, 8 June 2023 Officers are gagged from speaking out if they are placed on the list. Kim Bellware, Washington Post, 8 June 2023 That includes symptoms such as difficulty breathing, coughing, gagging, wheezing, asthma attack, lethargy, or chest pain. Brian Murphy, Washington Post, 13 July 2023 Signs include running noses, sneezing, gagging, coughing, weeping eyes and swollen eyes. José Criales-Unzueta, Vogue, 13 July 2023 In another drawing, a figure appears standing stiffly, blindfolded and gagged. Jamie Ducharme, Time, 7 June 2023 And Boy Erased had Nicole Kidman, which I was gagged by, and getting to work with Joel. Hiba Yazbek, New York Times, 14 June 2023 If your pet has been exposed to smoke, look for warning signs like coughing, gagging, panting, difficulty breathing, red or watery eyes, runny nose, fatigue, disorientation, and significantly decreased appetite, Teller says. 2023 Israeli military prosecutors will not pursue criminal charges against soldiers who detained and gagged a 78-year-old Palestinian American man and then left him unconscious in a building site shortly before he was pronounced dead. All rights reserved.Verb As reported by El País, the photo showed the five friends gagged and kneeling while displaying bloodied and bruised faces. Understanding GAG structure and function at molecular level with regard to development and health represents a unique opportunity in combating different kinds of human diseases.Ĭopyright © 2010 Elsevier Inc. Therefore, GAGs are essential components of modern molecular biology and human physiology. Abnormal protein/GAG aggregates are associated with a variety of devastating human diseases including, but not limited to, Alzheimer's, diabetes, prion or transmissible spongiform encephalopathies, Lupus, heparin-induced thrombocytopenia/thrombosis, and different kinds of cancers. Most importantly, protein/GAG aggregates induce thrombin generation and immune system upregulation by activating the contact system. GAGs regulate multiple signaling pathways including, but not limited to, fibroblast growth factor (FGF)/FGFR, hepatocyte growth factor (HGF)/c-Met, glial cell line-derived neurotrophic factor (GDNF)/c-Ret/GFRalpha1, vascular endothelial growth factor (VEGF)/VEGFR, platelet derived growth factor (PDGF)/PDGFR, BAFF/TACI, Indian hedgehog, Wnt, and BMP signaling pathways,where genetic studies have revealed an absolute requirement for GAGs in these pathways. GAGs catalyze protease (such as thrombin) inhibition by serpins. Such interactions protect growth factors, chemokines, and cytokines against proteolysis. Because of the expression repertoire of the GAG assembly and modification enzymes, each heparan sulfate and chondroitin sulfate chain has a sulfation pattern, chain length, and fine structure that is potentially unique to each animal cell. Two major types of glycosaminoglycan (GAG) polysaccharides, heparan sulfate and chondroitin sulfate, are polymerized and modified by enzymes that are encoded by more than 40 genes in animal cells.
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